Nalidixic acid and intracranial hypertension.

Acute intracranial hypertension after nalidixic acid administration.

Nalidixic acid (Negram) is an antimicrobial agent widely used in the treatment of urinary tract infection. Some years ago Boreus and Sundstrom (1967) reported intracranial hypertension in a 6-month-old boy treated with nalidixic acid at the manufacturer's recommended dose. Only a few cases have been reported since, mostly in children treated either with large doses (Fisher, 1967) or for prolong...

Intracranial hypertension in a child during treatment with nalidixic acid.

Nalidixic acid: an antibacterial paradox.

Nalidixic acid was found to be most bactericidal against various species of gram-negative bacteria at 50 to 200 mug/ml. With all species tested, increases in the concentration of nalidixic acid above this range reduced, rather than increased, its bactericidal effect so that, at levels in the region of 400 mug/ml, the drug was relatively bacteriostatic. Therefore, the mode of action of nalidixic...

Convulsions and hyperglycaemia associated with nalidixic acid.

Hyperglycaemia and convulsions in patients taking nalidixic acid are usually associated with overdosage of the drug or an underlying epileptic tendency.' :1 Nalidixic acid may also interfere with biochemical determinations of plasma and urinary glucose, giving falsepositive results. We describe an otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific ...

Nalidixic acid overdose and metabolic acidosis.

those who practise “less than” tertiary care medicine from our community is self-defeating. I believe that we will gain much more strength as a larger, more unified community. I would encourage CAEP and our EM community at large to engage in discussions about consolidated training, and wouldn’t argue against “fellowships” and other recognitions of distinction in training. I believe that our EM ...